The new GURPS
Ice Ageworldbook was written for prehistoric roleplaying,
and it makes a great "change of pace" campaign. It can be fun
to play characters who can't count beyond 4 . . . But it can serve as a
valuable sourcebook for other campaigns, too.
Post-Holocaust -- Use the book as is, but the setting is really
during a nuclear winter. The players may or may not realize, in the beginning,
that there are modern cities beneath the ice! The more primitive races of
human become devolved mutants.
Space--
Use it as a source-book for a primitive planet. The PCs may be explorers,
or they may be stranded there.
Cliffhangers
/ Pulps
/ Horror / Illuminati
-- Use it as a sourcebook for a "lost world" adventure, in a hollow
Earth or in a remote South American jungle. Throw dinosaurs in while you're
at it.
Fantasy -- The PCs travel to a far land, populated by primitives.
But some of the primitive shamans are very wise in their own special field
of magic; there will be things that they can teach even the most sophisticated
wizard!